Over the past two decades, we have seen tremendous advances on the simultaneous segmentation and estimation of a collection of models from sample data points, without knowing which points correspond to which model. Most existing segmentation methods treat this problem as "chicken-and-egg", and iterate between model estimation and data segmentation. This course will show that for a wide variety of data segmentation problems (e.g. mixtures of subspaces), the "chicken-and-egg" dilemma can be tackled using an algebraic geometric technique called Generalized Principal Component Analysis (GPCA). This technique is a natural extension of classical PCA from one to multiple subspaces. The course will also include several applications of GPCA to computer vision problems such as image/video segmentation, 3-D motion segmentation, and dynamic texture segmentation.